Trias E, Kovacs M, King PH, Si Y, Kwon Y, Varela V, Ibarburu S, Moura IC, Hermine O, Beckman JS, Barbeito L (2020) Schwann cells orchestrate peripheral nerve inflammation through the expression of CSF1, IL-34, and SCF in amyotrophic lateral sclerosis. Glia 68(6):1165-1181. doi: 10.1002/glia.23768 PMID: 31859421

Objective: To investigate the pathogenic significance of denervated Schwann cells (SCs) accumulating following impaired axonal growth in amyotrophic lateral sclerosis (ALS).

Summary: There is strong evidence for a previously unknown inflammatory mechanism triggered by SCs in ALS peripheral nerves that has broad application in developing novel therapies.

Usage: Immunohistochemistry (1:250); AB-N01AP: NGFr (mu p75) Rabbit Polyclonal

Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

Xiao D, Deng Q, Guo Y, Huang X, Zou M, Zhong J, Rao P, Xu Z, Liu Y, Hu Y, Shen Y, Jin K, Xiang M (2020) Generation of self-organized sensory ganglion organoids and retinal ganglion cells from fibroblasts. Sci Adv 6(22):eaaz5858. doi: 10.1126/sciadv.aaz5858 PMID: 32523990

Objective: To examine whether sensory ganglion (SG) organoids can be reprogrammed by transcription factors (TFs) into sensory ganglion (SG) neurons.

Summary: This study identifies a combination of triple TFs Ascl1, Brn3b/3a, and Isl1 (ABI) as an efficient means to reprogram mouse and human fibroblasts into self-organized and networked induced SG (iSG) organoids. iSG organoids may serve as a model to decipher the pathogenesis of sensorineural diseases and screen effective drugs and a source for cell replacement therapy.

Usage: Immunohistochemistry, Immunocytochemistry (1:500); AB-N01AP: NGFr (mu p75) Rabbit Polyclonal

Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

Wang F, Jing P, Zhan P, Zhang H (2020) Thyroid hormone in the pathogenesis of congenital intestinal dysganglionosis. Pediatr Dev Pathol 23(4):285-295. doi: 10.1177/1093526620908984 PMID: 32212960

Objective: To investigate the role of thyroid hormone (TH) in the pathogenesis of intestinal dysganglionosis (ID).

Summary: 6-propyl-2-thiouracil (PTU) inhibited TH production, reduced the number of enteric neurons, impaired intestinal motility, and impeded ENCC mitosis in zebrafish, suggesting a possible role of CH in the pathogenesis of ID.

Usage: Immunostaining (1:60); AB-N01AP: NGFr (mu p75) Rabbit Polyclonal

Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

Qin J, Wang M, Zhao T, Xiao X, Li X, Yang J, Yi L, Goffinet AM, Qu Y, Zhou L (2020) Early forebrain neurons and scaffold fibers in human embryos. Cerebral Cortex 30(3):913–928. doi: 10.1093/cercor/bhz136 PMID: 31298263

Objective: To study neural progenitor proliferation, neuronal migration, areal organization, and pioneer axon wiring are critical events during early forebrain development.

Summary: Axons from pioneer neurons in prethalamus, ventral telencephalon, and cortical preplate cross the diencephalon–telencephalon junction and the pallial–subpallial boundary, forming scaffolds that could guide thalamic and cortical axons at later stages.

Usage: Immunofluorescence (1:600); AB-N01AP: NGFr (mu p75) Rabbit Polyclonal, affinity-purified

Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

Ali A, Syed SM, Jamaluddin MFB, Colino-Sanguino Y, Gallego-Ortega D, Tanwar PS (2020) Cell lineage tracing identifies hormone-regulated and wnt-responsive vaginal epithelial stem cells. Cell Rep 30(5):1463-1477.e7. doi: 10.1016/j.celrep.2020.01.003 PMID: 32023462

Objective: To learn more about the role of Wnt signaling in vaginal epithelium (VE) homeostasis.

Summary: Data define heterogeneity in VE and identify VE stem cells. It was shown that canonical Wnt/b-catenin signaling is required for the proliferation and differentiation of VE stem cells.

Usage: histology and immunostaining (1:250)

Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)

Moreira da Silva Santos A, Gorman AM, Kelly JP, Doyle KM (2020) Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure. Neurosci Lett 715:134606. doi: 10.1016/j.neulet.2019.134606 PMID: 31693929

Objective: To investigate the effect of binge-like methamphetamine (MA) dosing on brain-derived neurotrophic factor (BDNF) levels and its receptors, trkB and p75NTR.

Summary: The binge-like regimen of MA affects expression of BDNF and its receptors, particularly the trkB receptor, in a time and region dependent manner, and highlights the importance of the frontal cortex and the striatum in the response following MA binge-like dosing.

Usage: Western blot (1:1000) NGFr (mu p75) Rabbit Polyclonal, affinity-purified

Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

McNamara M (2019) Development of novel therapies for marfan syndrome using a human iPSC-disease model. University of Cambridge Thesis. doi: 10.17863/CAM.38053

Objective: To address different strategies that could potentially be developed into treatments of Marfan Syndrome (MFS) for the clinic.

Summary: Preliminary results show that their disease model exhibits reduced GSK3β protein expression despite GSK3β inhibition proving to be beneficial in restoring some of the phenotypic features. Further experimental efforts need to be effectuated to harness precisely the GSK3β-dependent signaling pathways that govern the phenotypic abnormalities and characterize their MFS disease model.

Usage: immunocytochemistry (1:500)

Related Products: NGFR (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

Zhou Y (2019) PMP22 regulates lipid metabolism and cholesterol trafficking: The implication for hereditary peripheral neuropathies. University of Florida Thesis.

Objective: To study the extent of lipid abnormalities and to examine the underlying mechanisms, they determined the expression of lipid-related molecules, and studied morphological and functional alterations in the nerve, liver, and cultured cells from PMP22 KO mice.

Summary: The study reveals a novel role of PMP22 in regulating lipid metabolism and cholesterol trafficking, provide critical information for understanding the pathology of peripheral neuropathies, and shed light on the potential therapy for PMP22-linked neuropathies.

Related Products: NGFR (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

Ladd MR, Costello CM, Gosztyla C, Werts AD, Johnson B, Fulton WB, Martin LY, Redfield EJ, Crawford B, Panaparambil R, Sodhi CP, March JC, Hackam DJ (2019) Development of intestinal scaffolds that mimic native mammalian intestinal tissue. Tissue Eng Part A 25(17-18):1225-1241. doi: 10.1089/ten.TEA.2018.0239 PMID: 30652526

Objective: To develop a scaffold for the generation of an artificial intestine that specifically mimics the architecture and biomechanical properties of the native small intestine, and to evaluate the scaffold in vitro and in vivo.

Summary: Novel scaffolds were developed using PGS with promise for use in artificial intestine for individuals with short bowel syndrome.

Usage: Histology, immunohistochemistry, microscopy (1:500)

Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)

Wu SJ, Coarfa C, Abbas H, Checker R, Dhar S, Rajapakshe K, Lee MG, Flores ER (2019) ∆Np63 executes an oncogenic program through the regulation of a common landscape of super-enhancer associated genes in non-small cell lung cancer. Cell Reports 3420369. doi: 10.2139/ssrn.3420369

Objective: To investigate how ΔNp63 serves to maintain lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) through the regulation and maintenance of lung stem cells that are necessary for lung adenocarcinoma and squamous cell initiation and progression.

Summary: ∆Np63 maintains lung ADC and SCC by keeping lung stem cells in quiescence. ChIP-seq analysis of lung basal cells and alveolar type 2 (AT2) cells lacking ∆Np63 revealed a robust loss of activating histone marks at super enhancers of cell identity genes defining a unifying oncogenic role for ∆Np63 in non-small cell lung cancer.

Usage: staining

Related Products: NGFR (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)