Dwyer TA, Servatius RJ, Pang KC (2007) Noncholinergic lesions of the medial septum impair sequential learning of different spatial locations. J Neurosci 27:299-303. doi: 10.1523/JNEUROSCI.4189-06.2007
Summary: The medial septum and the vertical limb of the diagonal band of Broca (MSDB) have extensive connections to the hippocampus. In general, impairments due to loss of cholinergic neurons in this area have been smaller than those due to the loss of noncholinergic neurons. The authors treated rats with either 192-IgG-SAP (Cat. #IT-01) or kainic acid into each hemisphere of the medial septum. Behavioral testing following surgery demonstrated that the animals with noncholinergic lesions had impaired performance, even when compared to the animals with cholinergic lesions.
Related Products: 192-IgG-SAP (Cat. #IT-01)