Bailey AM, Lee JM (2007) Lesions to the nucleus basalis magnocellularis lower performance but do not block the retention of a previously acquired learning set. Brain Res 1136:110-121. doi: 10.1016/j.brainres.2006.12.028
Summary: A major source of cholinergic innervation to several cortices is the nucleus basalis magnocellularis (NBM). Rats were trained to acquire an olfactory discrimination learning set, then were lesioned with 192-IgG-SAP (Cat. #IT-01) or quisqualic acid. 0.075 µg of 192-IgG-SAP was administered in 2 sets of bilateral infusions. While treated animals performed poorly following the surgery, performance improved to better than expected by chance during the second trial. The authors discuss the role of the NBM in cognitive flexibility.
Related Products: 192-IgG-SAP (Cat. #IT-01)