Aztiria E, Capodieci G, Arancio L, Leanza G (2007) Extensive training in a maze task reduces neurogenesis in the adult rat dentate gyrus probably as a result of stress. Neurosci Lett 416(2):133-137. doi: 10.1016/j.neulet.2007.01.069
Summary: Ascending cholinergic inputs from the basal forebrain modulate hippocampal neurogenesis, although it is not clear if the modulation is direct or indirect. In this study rats experienced extended training in a spatial navigation task following 192-IgG-SAP (Cat. #IT-01) lesions. 192-IgG-SAP was injected into the basal forebrain nuclei and the cerebellar cortex. Although the lesioned animals displayed an 80% reduction in neuron proliferation in the dentate gyrus, extended training and learning did not affect proliferation.
Related Products: 192-IgG-SAP (Cat. #IT-01)