Cabrera SM, Chavez CM, Corley SR, Kitto MR, Butt AE (2006) Selective lesions of the nucleus basalis magnocellularis impair cognitive flexibility. Behav Neurosci 120:298-306. doi: 10.1037/0735-7044.120.2.298
Summary: In humans, one aspect of cognitive flexibility is being able to shift attention under a variety of pressures. Here the authors suggest that lesions to the cholinergic nucleus basalis magnocellularis (NBM) will impair cognitive flexibility. The NBM of rats was lesioned with 0.08 µg of 192-IgG-SAP (Cat. #IT-01). Both lesioned and controlled animals displayed a similar ability to learn a discrimination task, but lesioned animals displayed perseveration – the uncontrollable repetition of a previously correct response – indicating a loss of cognitive flexibility.
Related Products: 192-IgG-SAP (Cat. #IT-01)