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A putative flip-flop switch for control of REM sleep.

Lu J, Sherman D, Devor M, Saper CB (2006) A putative flip-flop switch for control of REM sleep. Nature 441(1):589-594. doi: 10.1038/nature04767

Summary: The authors propose a REM sleep regulatory system that involves GABAergic and glutaminergic neurons in the mesopontine tegmentum. Among other work, 2 ┬Ál of 0.1% orexin-SAP (Cat. #IT-20) was injected into the medial medullary reticular formation of rats. This work suggests the sharp transitions into and out of REM sleep are controlled by reciprocal interactions between GABAergic REM-off and REM-on neuronal populations.

Related Products: Orexin-B-SAP (Cat. #IT-20)

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