Lu J, Sherman D, Devor M, Saper CB (2006) A putative flip-flop switch for control of REM sleep. Nature 441(1):589-594. doi: 10.1038/nature04767
Summary: The authors propose a REM sleep regulatory system that involves GABAergic and glutaminergic neurons in the mesopontine tegmentum. Among other work, 2 µl of 0.1% orexin-SAP (Cat. #IT-20) was injected into the medial medullary reticular formation of rats. This work suggests the sharp transitions into and out of REM sleep are controlled by reciprocal interactions between GABAergic REM-off and REM-on neuronal populations.
Related Products: Orexin-B-SAP (Cat. #IT-20)