Scattoni ML, Adriani W, Calamandrei G, Laviola G, Ricceri L (2006) Long-term effects of neonatal basal forebrain cholinergic lesions on radial maze learning and impulsivity in rats. Behav Pharmacol 17(5-6):517-524. doi: 10.1097/00008877-200609000-00018
Summary: Work in the last decade has focused on clarifying the role of cholinergic dysfunction in Alzheimer’s disease. 7 day-old rats received 0.21 µg of 192-Saporin (Cat. #IT-01) administered to the third ventricle, and were tested at 5 months of age in delay tolerance and a radial maze. Test results suggest that prolonged basal forebrain cholinergic hypofunction is detectable only when using highly complex tasks.
Related Products: 192-IgG-SAP (Cat. #IT-01)