Willis CL, Ray DE, Marshall H, Elliot G, Evans JG, Kind CN (2006) Basal forebrain cholinergic lesions reduce heat shock protein 72 response but not pathology induced by the NMDA antagonist MK-801 in the rat cingulate cortex. Neurosci Lett 407(2):112-117. doi: 10.1016/j.neulet.2006.08.020
Summary: The NMDA receptor antagonist MK-801 may have use in establishing a model for schizophrenia. The mechanism by which cortical neurons are damaged by these antagonists is unknown. The authors tested the theory that cholinergic hyperstimulation of cingulate neurons is involved by administering 80 ng of 192-Saporin (Cat. #IT-01) unilaterally to rats. The results indicate that although cholinergic neurons are involved in the heat shock response to MK-801, the pathological effects follow a different pathway.
Related Products: 192-IgG-SAP (Cat. #IT-01)