Hawkes C, Kabogo D, Amritraj A, Kar S (2006) Up-regulation of cation-independent mannose 6-phosphate receptor and endosomal-lysosomal markers in surviving neurons after 192-IgG-saporin administrations into the adult rat brain. Am J Pathol 169(4):1140-1154. doi: 10.2353/ajpath.2006.051208
Summary: The cation-independent mannose 6-phosphate receptor (CI-MPR) plays a major role in the endosomal-lysosomal (EL) system. One of the tasks carried out by the EL system is clearance of abnormal proteins after injury. By administering 2.0 µg bilateral injections of 192-Saporin (Cat. #IT-01) to rats, the researchers were able to increase CI-MPR expression levels, as well as other EL markers in response to the lesion. The upregulation of EL components suggests that the EL system may be able to repair neuronal abnormalities induced by injury.
Related Products: 192-IgG-SAP (Cat. #IT-01)