Blanco-Centurion CA, Shiromani A, Winston E, Shiromani PJ (2006) Effects of hypocretin-1 in 192-IgG-saporin-lesioned rats. Eur J Neurosci 24(7):2084-2088. doi: 10.1111/j.1460-9568.2006.05074.x
Summary: The basal forebrain is a major arousal center. Using 6 µg of 192-Saporin (Cat. #IT-01) injected into the lateral ventricle of rats, the role of non-cholinergic neurons in the basal forebrain was investigated. Administration of orexin, also known as hypocretin, to lesioned animals produced sleep/wake patterns identical to non-lesioned animals. The results indicate that non-cholinergic neurons in the basal forebrain are sufficient to promote arousal in response to orexin.
Related Products: 192-IgG-SAP (Cat. #IT-01)