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  4. Noradrenergic inputs to the bed nucleus of the stria terminalis and paraventricular nucleus of the hypothalamus underlie hypothalamic-pituitary-adrenal axis but not hypophagic or conditioned avoidance responses to systemic yohimbine.

Noradrenergic inputs to the bed nucleus of the stria terminalis and paraventricular nucleus of the hypothalamus underlie hypothalamic-pituitary-adrenal axis but not hypophagic or conditioned avoidance responses to systemic yohimbine.

Banihashemi L, Rinaman L (2006) Noradrenergic inputs to the bed nucleus of the stria terminalis and paraventricular nucleus of the hypothalamus underlie hypothalamic-pituitary-adrenal axis but not hypophagic or conditioned avoidance responses to systemic yohimbine. J Neurosci 26(44):11442-11453. doi: 10.1523/JNEUROSCI.3561-06.2006

Summary: Yohimbine (YO) is an a2 adrenoceptor antagonist that increases transmitter release from adrenergic/noradrenergic (NA) neurons. The authors investigated whether NA inputs to the bed nucleus of the stria terminalis (BNST) were required for YO effects. After receiving 11 ng of anti-DBH-SAP (Cat. #IT-03) in the left and right BNST, rats displayed a marked decrease in the hypothalamic-pituitary-adrenal axis in response to YO administration.

Related Products: Anti-DBH-SAP (Cat. #IT-03)

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