Garcia-Alloza M, Zaldua N, Diez-Ariza M, Marcos B, Lasheras B, Javier Gil-Bea F, Ramirez MJ (2006) Effect of selective cholinergic denervation on the serotonergic system: implications for learning and memory. J Neuropathol Exp Neurol 65(11):1074-1081. doi: 10.1097/01.jnen.0000240469.20167.89
Summary: The authors compared two lesioning methods using 192-Saporin (Cat. #IT-01) to examine the role of the serotonergic system in learning and memory. 0.067 µg of conjugate administered to each hemisphere of the nucleus basalis of Meynert reduced cholinergic markers in the frontal cortex. 1 µg of conjugate administered to the ventricle of each hemisphere reduced cholinergic markers in the frontal cortex and hippocampus. Both models reduced serotonin levels in the frontal cortex, but only the ICV injections modified learning.
Related Products: 192-IgG-SAP (Cat. #IT-01)