Milstein JA, Lehmann O, Theobald DE, Dalley JW, Robbins TW (2007) Selective depletion of cortical noradrenalin by anti-dopamine beta-hydroxylase-saporin impairs attentional function and enhances the effects of guanfacine in the rat. Psychopharmacology (Berl) 190(1):51-63. doi: 10.1007/s00213-006-0594-x
Summary: Building on previous work, the authors examined the effect of cortical noradrenalin depletion on a reaction time task. Rats received 0.2 µg-intracortical infusions of anti-DBH-SAP (Cat. #IT-03), then were trained in a reaction time task. The effect of guanfacine, a selective a-2 adrenergic agonist was also tested in these animals. Lesioned rats were not impaired on the baseline task, but were slower and less accurate during high rate conditions. Guanfacine only affected the lesioned animals.
Related Products: Anti-DBH-SAP (Cat. #IT-03)