Fransson J, Borrebaeck CA (2006) The nuclear DNA repair protein Ku70/80 is a tumor-associated antigen displaying rapid receptor mediated endocytosis. Int J Cancer 119(10):2492-2496. doi: 10.1002/ijc.22212
Summary: The protein Ku70/80 is expressed in the nucleus of all cells. Tumor cell lines, however, have been shown to express Ku70/80 on the cell surface. In this study, the authors show that Ku70/80 is internalized into pancreatic carcinoma cells upon binding of the antibody INCA-X. INCA-X was combined with Mab-ZAP (Cat. #IT-04) and applied to several pancreatic carcinoma cell lines in vitro. Cell death in some of the treated lines demonstrates the potential of Ku70/80 as a therapeutic target.
Related Products: Mab-ZAP (Cat. #IT-04)