Nguyen DH, Ball ED, Varki A (2006) Myeloid precursors and acute myeloid leukemia cells express multiple CD33-related Siglecs. Exp Hematol 34(6):728-735. doi: 10.1016/j.exphem.2006.03.003
Summary: Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of cell surface receptors which bind to sialic acid. They are found mainly on leukocytes, and also on acute myeloid leukemia (AML) cells. The authors tested several anti-Siglec antibodies against U937 histiocytic lymphoma cells and THP-1 acute monocytic leukemia cells in vitro. When these antibodies were combined with Mab-ZAP (Cat. #IT-04), a second immunotoxin, the target cells were eliminated. The data suggest that Siglecs may be a viable target for AML therapy.
Related Products: Mab-ZAP (Cat. #IT-04)