Dinh TT, Flynn FW, Ritter S (2006) Hypotensive hypovolemia and hypoglycemia activate different hindbrain catecholamine neurons with projections to the hypothalamus. Am J Physiol Regul Integr Comp Physiol 291(4):R870-R879. doi: 10.1152/ajpregu.00094.2006
Summary: Hypovolemia, a decrease in blood plasma volume, results in secretion of arginine vasopressin (AVP). This work investigates the role of hindbrain catecholamine neurons in hypovolemia-induced AVP secretion. Rats were treated with bilateral 42 ng injections of anti-DBH-SAP (Cat. #IT-03) into the paraventricular nucleus of the hypothalamus, and hypovolemia was induced by blood withdrawal. Treated animals displayed severely impaired AVP response, as well as lower food intake and corticosterone secretion in response to insulin.
Related Products: Anti-DBH-SAP (Cat. #IT-03)