Fontan-Lozano A, Troncoso J, Munera A, Carrion AM, Delgado-Garcia JM (2005) Cholinergic septo-hippocampal innervation is required for trace eyeblink classical conditioning. Learn Mem 12(6):557-563. doi: 10.1101/lm.28105
Summary: Classical conditioning of eyeblink responses can be used to evaluate cognitive deficits. The authors lesioned the medial septum/diagonal band of rats with 200 ng of 192-IgG-SAP (Cat. #IT-01), then examined classical and instrumental conditioning paradigms. Lesioned animals displayed a deficit in the acquisition, but not retrieval of eyeblink classical conditioning. The deficit was reversed by carbachol, a cholinergic muscarinic agonist, suggesting a role for the muscarinic system in the acquisition of new motor abilities.
Related Products: 192-IgG-SAP (Cat. #IT-01)