Hawkes C, Jhamandas JH, Kar S (2005) Selective loss of basal forebrain cholinergic neurons by 192 IgG-saporin is associated with decreased phosphorylation of Ser glycogen synthase kinase-3beta. J Neurochem 95(1):263-272. doi: 10.1111/j.1471-4159.2005.03363.x
Summary: Glycogen synthase kinase-3ß (GSK-3ß) is an enzyme involved in a variety of biological events. In this study the authors examined the potential role of GSK-3ß in degeneration of basal forebrain cholinergic neurons. Rats were treated with 2.0 µg per ventricle injections of 192-IgG-SAP (Cat. #IT-01), then GSK-3ß and other cholinergic marker levels were assayed. The results indicate that increased GSK-3ß activity can provide some protection from 192-IgG-SAP-induced degeneration of forebrain cholinergic neurons.
Related Products: 192-IgG-SAP (Cat. #IT-01)