Kuczewski N, Aztiria E, Leanza G, Domenici L (2005) Selective cholinergic immunolesioning affects synaptic plasticity in developing visual cortex. Eur J Neurosci 21(7):1807-1814. doi: 10.1111/j.1460-9568.2005.04014.x
Summary: In this study the authors examined the role of subcortical cholinergic inputs in the regulation of plastic events in the visual cortex during early postnatal development. Four-day-old mouse pups were treated with a total of 0.4 µg of 192-Saporin (Cat. #IT-01), using bilateral injections. Analysis of muscarinic receptor mRNA, long-term potentiation of cortex slices, and theta burst stimulation indicated that synaptic transmission and plasticity of the developing visual cortex depends on cholinergic input.
Related Products: 192-IgG-SAP (Cat. #IT-01)