Paban V, Jaffard M, Chambon C, Malafosse M, Alescio-Lautier B (2005) Time course of behavioral changes following basal forebrain cholinergic damage in rats: Environmental enrichment as a therapeutic intervention. Neuroscience 132(1):13-32. doi: 10.1016/j.neuroscience.2004.11.024
Summary: In this study the authors examined the effects of 192-Saporin (Cat. #IT-01) administration to the medial septum (37.5 ng/side) and nucleus basalis magnocellularis (75 ng/side) of rats. The results suggest that behavioral deficits immediately after lesioning are due to cholinergic depletion, while deficits later in life may be connected to a gradual degeneration process. Environmental enrichment had a significant positive effect on lesioned rats, indicating a level of cognitive plasticity.
Related Products: 192-IgG-SAP (Cat. #IT-01)