Turchi J, Saunders RC, Mishkin M (2005) Effects of cholinergic deafferentation of the rhinal cortex on visual recognition memory in monkeys. Proc Natl Acad Sci U S A 102(6):2158-2161. doi: 10.1073/pnas.0409708102
Summary: The rhinal cortex has been shown to play a critical role in recognition memory. The investigators examined the effect of eliminating cholinergic input to the rhinal cortex on the formation of new visual memories in macaques. Animals were given 0.01 µg injections of ME20.4-SAP (Cat. #IT-15) into the perirhinal and entorhinal cortices. The selective cholinergic deafferentation produced a substantial impairment of visual recognition memory, suggesting that cholinergic activation is essential for the formation of new visual memories.
Related Products: ME20.4-SAP (Cat. #IT-15)