Harrell LE, Parsons DS, Kolasa K (2005) Pro- and anti-apoptotic evidence for cholinergic denervation and hippocampal sympathetic ingrowth in rat dorsal hippocampus. Exp Neurol 194(1):182-190. doi: 10.1016/j.expneurol.2005.02.009
Summary: Cholinergic denervation of the hippocampus results in hippocampal sympathetic ingrowth (HSI) of fibers from the superior cervical ganglion; this ingrowth may exert an anti-apoptotic effect. After 1-µg injections of 192-Saporin (Cat. #IT-01) into the medial septum of rats, the authors investigated the levels of apoptotic protein expression and DNA fragmentation. The findings suggest that cholinergic denervation causes pro-apoptotic responses, but HSI exerts a protective effect against programmed cell death.
Related Products: 192-IgG-SAP (Cat. #IT-01)