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Elimination of rat spinal neurons expressing neurokinin 1 receptors reduces bladder overactivity and spinal c-fos expression induced by bladder irritation.

Elimination of rat spinal neurons expressing neurokinin 1 receptors reduces bladder overactivity and spinal c-fos expression induced by bladder irritation.

Seki S, Erickson KA, Seki M, Nishizawa O, Igawa Y, Ogawa T, de Groat WC, Chancellor MB, Yoshimura N (2005) Elimination of rat spinal neurons expressing neurokinin 1 receptors reduces bladder overactivity and spinal c-fos expression induced by bladder irritation. Am J Physiol Renal Physiol 288(3):F466-F473. doi: 10.1152/ajprenal.00274.2004

Summary: Substance P is reported to play a role in the micturition reflex as well as in nociceptive responses. The authors investigated the role that neurokinin-1 receptor-expressing cells in the spinal cord play in the micturition reflex of rats. 8 µl of 1.0 or 1.5 µM SSP-SAP (Cat. #IT-11) was injected into the L6-S1 level of the spinal cord, and cystometric parameters were measured before and after capsaicin administration to the bladder. Lesioned animals did not display the bladder overactivity normally seen in the presence of capsaicin.