Mohapel P, Leanza G, Kokaia M, Lindvall O (2005) Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning. Neurobiol Aging 26:939-946. doi: 10.1016/j.neurobiolaging.2004.07.015
Summary: New hippocampal neurons that are thought to be involved in memory formation are generated in the dentate gyrus (DG) throughout adulthood. In this study, rats were injected at various sites with 192-Saporin (Cat. #IT-01). The authors found that acetylcholine levels, which are reduced upon administration of 192-Saporin, are linked to proliferation and/or short-term survival of DG neurons, rather than long-term survival or differentiation. Cognitive defects that could be linked to the reduced number of new neurons were also observed.
Related Products: 192-IgG-SAP (Cat. #IT-01)