Tarpley JW, Kohler MG, Martin WJ (2004) The behavioral and neuroanatomical effects of IB(4)-saporin treatment in rat models of nociceptive and neuropathic pain. Brain Res 1029(1):65-76. doi: 10.1016/j.brainres.2004.09.027
Summary: Using the fact that primary afferent neurons bind isolectin B4 (IB4), the authors injected 5 µg of IB4-SAP (Cat. #IT-10) into the sciatic nerve in the left thigh. After recovery, these animals were then treated with a L5 spinal nerve ligation. Lesioned animals displayed attenuated NGF-induced hyperalgesia, as well as differences in other pain-model markers. The data indicate that IB4-positive C-fibers play a discrete role in NGF-induced hyperalgesia, as well as in the development of neuropathic pain.
Related Products: IB4-SAP (Cat. #IT-10)