Conner JM, Culberson A, Packowski C, Chiba AA, Tuszynski MH (2003) Lesions of the basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Neuron 38(5):819-829. doi: 10.1016/s0896-6273(03)00288-5
Summary: Neuronal plasticity has been associated with normal learning. The authors wished to investigate the role of the cholinergic basal forebrain (CBF) system in learning motor skills. Rats received bilateral 95-ng injections of 192-Saporin (Cat. #IT-01) in either the medial septum, the nucleus basalis magnocellularis, or both. The results indicate that lesioned animals, with many aspects of attention still preserved, are unable to adapt attention to meet the demands of a particular task. The authors conclude that the CBF system may be implicated in learning forms that require plasticity of cortical representations.
Related Products: 192-IgG-SAP (Cat. #IT-01)