Kirby BP, Rawlins JN (2003) The role of the septo-hippocampal cholinergic projection in T-maze rewarded alternation. Behav Brain Res 143(1):41-48. doi: 10.1016/s0166-4328(03)00005-6
Summary: 192-Saporin (Cat. #IT-01) has been used extensively to lesion cholinergic projections to the medial septum from the hippocampal region. It is not yet clear how post-lesion neural regeneration may affect the results. The authors used four 50-ng injections of 192-Saporin to investigate effects prior to any suspected neural regeneration. Significant microglia activation, loss of hippocampal acetylcholinesterase, and a clear inflammatory response were observed; but there was no impairment of spatial working memory.
Related Products: 192-IgG-SAP (Cat. #IT-01)