Ricceri L (2003) Behavioral patterns under cholinergic control during development: lessons learned from the selective immunotoxin 192 IgG saporin. Neurosci Biobehav Rev 27(4):377-384. doi: 10.1016/s0149-7634(03)00068-x
Summary: The author reviews the effects of 192-Saporin (Cat. #IT-01) neonatal lesions (0.42 µg in each hemisphere) on the cholinergic basal forebrain system in rats. Short-term effects are seen in pups in learning tasks, as well as ultrasound vocalizations. Longer term effects are seen in task-specific behaviors. Data suggest that the extent of these effects are linked to the attentional load of the task. The age of the animal when lesioned may also play a role in the extent of the deficits caused by 192-Saporin; studies show that early in the first week of life is a particularly vulnerable period.
Related Products: 192-IgG-SAP (Cat. #IT-01)