Hilgert M, Hartmann J, Loffelholz K, Jeltsch H, Cassel JC, Klein J (2003) Effects of septal grafts on acetylcholine release from rat hippocampus after 192 IgG-saporin lesion. Neurochem Res 28(3-4):467-472. doi: 10.1023/a:1022852819018
Summary: A model for transplantation efficacy was created using injections of 400 ng each into the vertical limb of the rat diagonal band of Broca and the medial septum for the specific removal of cholinergic neurons. Thirteen months after lesioning, sham-operated animals had measured acetylcholine release at 20% of control. 192-Saporin (Cat. #IT-01)-lesioned animals were transplanted with fetal septal cells 15 days after lesioning. Thirteen months later, their septal level of acetylcholine release was near normal (71%) of controls. A serotonin uptake inhibitor briefly stimulated acetylcholine release similar to sham control animals.
Related Products: 192-IgG-SAP (Cat. #IT-01)