Sesack SR, Hawrylak VA, Matus C, Guido MA, Levey AI (1998) Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter. J Neurosci 18(7):2697-2708. doi: 10.1523/JNEUROSCI.18-07-02697.1998 PMID: 9502827
Objective: To determine whether the reportedly greater diffusion of dopamine in the rat prefrontal cortex (PFC) as compared with the striatum is associated with a more restricted axonal distribution of the cortical DAT protein.
Summary: Results suggest that considerable extracellular diffusion of dopamine in the prelimbic PFC may result, at least in part, from a paucity of DAT content in mesocortical dopamine axons, as well as a distribution of the DAT protein at a distance from synaptic release sites. Also, different populations of dopamine neurons may selectively target the DAT to different subcellular locations.
Usage: electron microscopy
Related Products: Dopamine Transporter Rat Monoclonal (DAT-NT) (Cat. #AB-N18)