Jasmin L, Boudah A, Ohara PT (2003) Long-term effects of decreased noradrenergic central nervous system innervation on pain behavior and opioid antinociception. J Comp Neurol 460(1):38-55. doi: 10.1002/cne.10633
Summary: Noradrenaline (NA) is an essential element of the endogenous pain inhibitory system. The authors injected 5 µg of anti-DBH-SAP (Cat. #IT-03) into either the cerebral ventricles or lumbosacral cistern of rats to investigate whether a permanent reduction of noradrenergic innervation of the spinal cord leads to a chronic decreased nociceptive threshold. Although treated animals were less responsive to the antinociceptive effects of morphine, the results suggest that NA makes only a modest contribution to the nociceptive threshold.
Related Products: Anti-DBH-SAP (Cat. #IT-03)