1. Home
  2. Knowledge Base
  3. References
  4. Selective joint denervation promotes knee osteoarthritis in the aging rat.

Selective joint denervation promotes knee osteoarthritis in the aging rat.

Salo PT, Hogervorst T, Seerattan RA, Rucker D, Bray RC (2002) Selective joint denervation promotes knee osteoarthritis in the aging rat. J Orthop Res 20(6):1256-1264. doi: 10.1016/S0736-0266(02)00045-1

Summary: Noting that mice lose joint afferents with aging, and that this loss precedes osteoarthritis development, the authors investigated the effects of denervating the knee joints of young rats. Injection of 10 ┬Ál OX7-SAP (Cat. #IT-02) into the knee joint space produced severe degenerative cartilage changes as well as a significant reduction in the number of joint afferents. These changes indicate that joint denervation predisposes a joint to osteoarthritic changes more severe than those found with aging alone.

Related Products: OX7-SAP (Cat. #IT-02)

Shopping Cart
Scroll to Top