Silveira DC, Cha BH, Holmes GL (2002) Effects of lesions of basal forebrain cholinergic neurons in newborn rats on susceptibility to seizures. Dev Brain Res 139:277-283. doi: 10.1016/s0165-3806(02)00586-2
Summary: It has previously been shown that adult rats treated with the cholinergic lesioning agent 192-Saporin (Cat. #IT-01) display increased susceptibility to generalized seizures. Here, the authors studied the effects of 200 ng intracerebroventricular injections of 192-Saporin in neonatal rats. Although treated rats did not demonstrate differences in seizure duration or EEG ictal duration, a significantly shorter latency to seizure onset was observed. No significant differences were observed in spatial learning between treated and control rats.
Related Products: 192-IgG-SAP (Cat. #IT-01)