Bechade C, Mallecourt C, Sedel F, Vyas S, Triller A (2002) Motoneuron-derived neurotrophin-3 is a survival factor for PAX2-expressing spinal interneurons. J Neurosci 22(20):8779-8784. doi: 10.1523/JNEUROSCI.22-20-08779.2002
Summary: In the rat, half of motoneurons die between embryonic day 15 and postnatal day 1. Programmed cell death of interneurons is not as well characterized. The authors cultured explants of brachial neural tubes from rat embryos in the presence of 200 ng/ml of 192-Saporin (Cat. #IT-01). Although 192-Saporin had no direct effect on interneurons in culture, elimination of p75-neurotrophin receptor-expressing neurons caused the interneurons to die.
Related Products: 192-IgG-SAP (Cat. #IT-01)