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  4. Selective immunolesioning of the basal forebrain cholinergic neurons in rats: effect on attention using the 5-choice serial reaction time task.

Selective immunolesioning of the basal forebrain cholinergic neurons in rats: effect on attention using the 5-choice serial reaction time task.

Risbrough V, Bontempi B, Menzaghi F (2002) Selective immunolesioning of the basal forebrain cholinergic neurons in rats: effect on attention using the 5-choice serial reaction time task. Psychopharmacology 164:71-81. doi: 10.1007/s00213-002-1170-7

Summary: The authors used 0.067 µg injections of 192-Saporin (Cat. #IT-01) into the nucleus basalis magnocellularis to investigate attentional performance in rats. The treated animals exhibited a very specific subset of attentional deficits, many centered around increased difficulty completing tasks in the presence of distractions.

Related Products: 192-IgG-SAP (Cat. #IT-01)

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