Ricceri L, Hohmann C, Berger-Sweeney J (2002) Early neonatal 192 IgG saporin induces learning impairments and disrupts cortical morphogenesis in rats. Brain Res 954(2):160-172. doi: 10.1016/s0006-8993(02)03172-4
Summary: Previous data have shown that cholinergic lesions on postnatal day (pnd) 7 in rats produce learning impairments on pnd 15. Using 0.2 µg injections of 192-Saporin (Cat. #IT-01) into the lateral ventricles, the authors investigated the effect of lesioning animals at pnd 1 and 3. The treated animals demonstrated sex-specific deficits in some cognitive behaviors, as well as changes in neurochemistry and cortical organization.
Related Products: 192-IgG-SAP (Cat. #IT-01)