Helm KA, Han JS, Gallagher M (2002) Effects of cholinergic lesions produced by infusions of 192 IgG-saporin on glucocorticoid receptor mRNA expression in hippocampus and medial prefrontal cortex of the rat. Neuroscience 115(3):765-774. doi: 10.1016/s0306-4522(02)00487-6
Summary: The authors investigated the loss of cholinergic support from the basal forebrain, a hallmark of aging, on glucocorticoid receptor mRNA expression in various target sites. 192-Saporin (Cat. #IT-01) was injected into either the nucleus basalis magnocellularis/substantia innominata (0.2 µl of 0.25 mg/ml) or the medial septum/vertical limb of the diagonal band (0.3 µl of 0.25 mg/ml). Treated rats sustained a significant decrease in glucocorticoid receptor mRNA levels in the hippocampus and medial prefrontal cortex.
Related Products: 192-IgG-SAP (Cat. #IT-01)