Hartonian I, Mufson EJ, de Lacalle S (2002) Long-term plastic changes in galanin innervation in the rat basal forebrain. Neuroscience 115(3):787-795. doi: 10.1016/s0306-4522(02)00453-0
Summary: One hallmark of Alzheimer’s disease is the hyperinnervation of surviving cholinergic basal forebrain neurons with galanin-IR fibers. This may exacerbate the cholinergic deficit. The authors injected 192-Saporin (140 nl of 0.075 mg/ml, Cat. #IT-01) into the diagonal band of Broca of rats. An increase in galanin immunoreactivity was observed as early as 1 hour post-injection, and persisted as long as 6 months.
Related Products: 192-IgG-SAP (Cat. #IT-01)