Stowell JR, Berntson GG, Sarter M (2000) Attenuation of the bidirectional effects of chlordiazepoxide and FG 7142 on conditioned response suppression and associated cardiovascular reactivity by loss of cortical cholinergic inputs. Psychopharmacol 150(2):141-149. doi: 10.1007/s002130000443
Summary: The benzodiazepine receptor (BR) is involved in anxiety. It has been hypothesized that cholinergic projections from the CBF are necessary for modulation of the BR by agonists and inverse agonists. Stowell et al. directly injected 0.18 µg 192-Saporin (Cat #IT-01) into each hemisphere of the CBF in adult rats. The treated rats had altered responses to external stimuli during an operant conditioned task. These results indicate that the CBF plays an important role in response to fear and anxiety-related stimuli. This system may also mediate the actions of BR ligands.
Related Products: 192-IgG-SAP (Cat. #IT-01)