Wiley RG, Stirpe F, Thorpe P, Oeltmann TN (1989) Neuronotoxic effects of monoclonal anti-Thy 1 antibody (OX7) coupled to the ribosome inactivating protein, saporin, as studied by suicide transport experiments in the rat. Brain Res 505:44-54. doi: 10.1016/0006-8993(89)90114-5 PMID: 2575436
Summary: The authors discuss the use of an antibody-saporin conjugate via retrograde transport (suicide transport). It is important to note that saporin conjugates with non-antibody targeting agents will most likely NOT be retrogradely transported.
Usage: Purified anti-Thy 1.1 conjugated to Saporin (9 mcg) was injected systemically in rats.
Related Products: OX7-SAP (Cat. #IT-02)