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Impaired acquisition of a Morris water maze task following selective destruction of cerebellar Purkinje cells with OX7-saporin.

Impaired acquisition of a Morris water maze task following selective destruction of cerebellar Purkinje cells with OX7-saporin.

Gandhi CC, Kelly RM, Wiley RG, Walsh TJ (2000) Impaired acquisition of a Morris water maze task following selective destruction of cerebellar Purkinje cells with OX7-saporin. Behav Brain Res 109:37-47. doi: 10.1016/s0166-4328(99)00160-6

Summary: The cerebellum has been associated with the control of motor activity and voluntary movements. Recent data have shown the cerebellum may also play a role in “higher order” processes such as learning, language, and cognition. Using 2 µg OX7-SAP (Cat. #IT-02) by i.c.v. injection, Gandhi et al. selectively eliminated Purkinje cells in rat cerebellum in order to examine the ability of treated animals to complete a water maze task. Elimination of these cells significantly impaired the ability of the rats to complete the task, suggesting the cerebellum is involved in learning.