Angner RT, Kelly RM, Wiley RG, Walsh TJ, Reuhl KR (2000) Preferential destruction of cerebellar Purkinje cells by OX7-saporin. Neurotoxicol 21:395-403.
Summary: Purkinje cells function as inhibitors and are the sole output of the cerebellar cortex. Angner et al. eliminate these cells in rats with 1-2 µg OX7-SAP (Cat. #IT-02), an immunotoxin that binds the Thy 1.1 antigen. The treated rats show effects of loss of inhibitory control, including a time-dependent increase in motor activity and decreased motor coordination.
Related Products: OX7-SAP (Cat. #IT-02)