Martin WJ, Gupta NK, Loo CM, Rohde DS, Basbaum AI (1999) Differential effects of neurotoxic destruction of descending noradrenergic pathways on acute and persistent nociceptive processing. Pain 80:57-65. doi: 10.1016/s0304-3959(98)00194-8
Summary: The authors used Anti-DBH-SAP to re-examine the contribution of noradrenergic pathways to nociception and to morphine analgesia. They also evaluated morphine analgesia in the formalin test and found that toxin-treated animals exhibited enhanced morphine analgesia. These results establish the utility of using this immunotoxin to selectively destroy subpopulations of noradrenergic cell groups and provide evidence that acute and persistent nociception are differentially regulated by descending noradrenergic pathways.
Usage: Intrathecal treatment with Anti-DBH-SAP attenuates formalin pain (5.0 µg/20 µl).
Related Products: Anti-DBH-SAP (Cat. #IT-03)