The role of the nucleus basalis of meynert in neuromodulation therapy: A systematic review from the perspective of neural network oscillations

Jiao L, Kang H, Geng Y, Liu X, Wang M, Shu K (2024) The role of the nucleus basalis of meynert in neuromodulation therapy: A systematic review from the perspective of neural network oscillations. Front Aging Neurosci 16:1376764. doi: 10.3389/fnagi.2024.1376764 PMID: 38650866

Objective: To review previous animal studies of NBM lesions, NBM-DBS models, and clinical case studies to summarize the important functions of the NBM in neuromodulation.

Summary: Authors reviewed studies showing effects of the NBM on the neural network in arousal, sleep and epilepsy, effects of the NBM on the neural network –evidence from NBM injury animal models, and neuromodulation effects of NBM-DBS in animal models.

Related Products: 192-IgG-SAP (Cat. #IT-01)

See Also:

• Berdiev RK et al. The role of the nucleus basalis of Meynert and reticular thalamic nucleus in pathogenesis of genetically determined absence epilepsy in rats: A lesion study. Brain Res 1185:266-274, 2007.
• Ljubojevic V et al. Cholinergic modulation of frontoparietal cortical network dynamics supporting supramodal attention. J Neurosci 38:3988-4005, 2018.
• Berntson GG et al. Specific contributions of the basal forebrain corticopetal cholinergic system to electroencephalographic activity and sleep/waking behaviour. Eur J Neurosci 16(12):2453-2461, 2002.
• Dezawa S et al. Lesions of the nucleus basalis magnocellularis (Meynert) induce enhanced somatosensory responses and tactile hypersensitivity in rats. Exp Neurol 335:113493, 2021.