Wang W, Zhang Y, Li L, Xu Y, Zhang W, Chen X, Wang X, Tong G, Zhang P (2026) PACAP/PAC 1 modulates light-induced sleep via the ipRGC-VLPO pathway. Biochem Biophys Res Commun 808:153462. doi: 10.1016/j.bbrc.2026.153462 PMID: 41702189
Objective: To investigate the mechanism of PACAP in ipRGC–VLPO light-induced sleep.
Summary: Partial ablation of ipRGCs by Melanopsin-SAP reduced light-induced sleep duration, whereas PACAP 1-38 administration reversed this effect, leading to an increase in REM sleep. After the partial destruction of ipRGCs through the intraocular injection of saporin (SAP), we continued to observe the effect of PACAP on light-induced sleep. The results showed that after the microdialysis injection of PACAP 1-38 into the VLPO of SAP mice, the light-induced sleep of the mice increased; specifically, REM sleep significantly increased. The results suggest that PACAP is involved in ipRGC–VLPO-mediated light-induced sleep.
Related Products: Melanopsin-SAP (Cat. #IT-44)