Yin S, Tao Y, Li T, Li C, Cui Y, Zhang Y, Yin S, Zhao L, Hu P, Cui L, Wu Y, He Y, Yu S, Chen J, Lu S, Qiu G, Song M, Hou Q, Qian C, Zou Z, Xu S, Yu Y (2024) Itaconate facilitates viral infection via alkylating GDI2 and retaining Rab GTPase on the membrane. Signal Transduct Target Ther 9(1):371. doi: 10.1038/s41392-024-02077-8 PMID: 39730330
Objective: To demonstrate that the IRG1-itaconate axis facilitates the infections of vesicular stomatitis virus (VSV) and influenza A virus (IAV) in macrophages and epithelial cells via Rab GTPases redistribution.
Summary: The study reveals that neutrophils-derived itaconate facilitates viral infection via redistribution of Rab GTPases, suggesting potential targets for antiviral therapy.
Usage: Immunofluorescence: cells were fixed in PBS solution containing 4% formaldehyde, permeabilized with 0.2% saporin (PR-01) along with a mixture of 5% BSA and 10% FCS
Related Products: Saporin (Cat. #PR-01)