Gritton HJ, Stasiak AM, Sarter M, Lee TM (2013) Cognitive performance as a zeitgeber: cognitive oscillators and cholinergic modulation of the SCN entrain circadian rhythms. PLoS One 8(2):e56206. doi: 10.1371/journal.pone.0056206 PMID: 23441168
Objective: To examine how attention-demanding task performance interacts with circadian mechanisms in the SCN.
Summary: The authors used site-specific injections of the 192 IgG-SAP to selectively eliminate cholinergic projections to the SCN originating from the basal forebrain, thereby testing the necessity of forebrain cholinergic neurotransmission in mediating entrainment to cognitive tasks. The findings provide a basis for the hypothesis that in vivo cholinergic signaling, modulated by cognitive demand, entrains non-SCN oscillators and promotes diurnal activity through cholinergic-SCN interactions.
Usage: Rats received 0.4 µL per hemisphere of a 200 ng/µL of 192 IgG-SAP (IT-01) suspended in artificial cerebro-spinal fluid (ACSF).
Related Products: 192-IgG-SAP (Cat. #IT-01)