Chaskiel L, Dantzer R, Konsman JP (2021) Brain Perivascular Macrophages Do Not Mediate Interleukin-1-Induced Sickness Behavior in Rats. Pharmaceuticals (basel) 14(10):1030. doi: 10.3390/ph14101030 PMID: 34681254
Objective: To assess the role of brain perivascular macrophages in mediating IL-1β-induced sickness behavior in rats
Summary: Icv IL-1β-saporin administration resulted in a reduction in brain perivascular macrophages, without altering subsequent icv or ip IL-1β-induced reductions in food intake, loco-motor activity, and social interactions. In conclusion, the present work shows that icv IL-1β-saporin administration is an efficient way to target brain perivascular macrophages, and to determine whether these cells are involved in IL-1β-induced sickness behavior.
Usage: intracerebroventricular (icv) administration of 1.75μg IL-1β-saporin
Related Products: Saporin (Cat. #PR-01)