Ishtiaque S, Ahman S, Farooqui A, Siddiqui MH, Faridi SA (2025) Multifunctional nanoparticles to over come ABC transporter-mediated drug resistance in cancer: A short review. IJERT 13(6)
Objective: To examine innovative multifunctional nanoparticle strategies designed to overcome transporter-mediated efflux mechanism.
Summary: Authors analyze nanocarrier platforms enabling targeted co-delivery of chemotherapeutics with transporter inhibitors, gene-silencing approaches suppressing efflux pump expression, and stimuli-responsive systems exploiting tumor microenvironment features. The work highlights emerging technologies including nanobots and AI-designed nanoparticles while addressing translational challenges like protein corona formation and manufacturing scalability.
Usage: Lipid-SAP (EC16-1/saporin) was mentioned as one of the selected preclinical studies of nanoparticle platforms targeting ABC transporter-mediated drug resistance.
Related Products: Saporin (Cat. #PR-01)